Computations in neural circuits

We investigate how neural circuits process information from both the external environment and the body’s internal state. We study the computations performed by neural circuits, how learning reshapes circuit function, and how interoceptive signals influence neural activity to shape cognition and behaviour, using multi-photon imaging, electrophysiology, optogenetics, and computational modelling.


Exploring Neural Circuits

 Some examples of the methods we employ to interrogate neural circuits

2-photon imaging of inhibitory PG cells responding to 12 odours
OMMI
We have developed Optical MultiModal Imaging (OMMI) enabling simultaneous imaging of structural, intrinsic-optical, and fluorescent signals, available here
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Electrophysiology: Paired recording of mitral-mitral cell synapses in the main olfactory bulb
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Optogenetics: An image stack through the glomerular layer of a mouse expressing YFP-tagged Channelrhodopsin-2
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Computational modelling: A realistic model of a retinal ganglion cell and the excitatory and inhibitory synapses of the inner plexiform layer of the retina