Johnston Lab

Neural Circuits and Sensing Lab

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about

We study how neural circuits encode sensory information, and how that encoding is shaped by learning and the body’s internal state. Our research centres on olfactory circuits and plasticity, and on metabolic modulation of neural activity, two themes that converge in the olfactory bulb.

How we explore neural circuits

2-photon imaging of inhibitory PG cells responding to 12 odours
OMMI
We have developed Optical MultiModal Imaging (OMMI) enabling simultaneous imaging of structural, intrinsic-optical, and fluorescent signals, available here
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Electrophysiology: Paired recording of mitral-mitral cell synapses in the main olfactory bulb
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Optogenetics: An image stack through the glomerular layer of a mouse expressing YFP-tagged Channelrhodopsin-2
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Computational modelling: A realistic model of a retinal ganglion cell and the excitatory and inhibitory synapses of the inner plexiform layer of the retina