Computations in neural circuits

We are interested in how the brain is able to perceive and respond to the external world. We seek to understand this by studying how neural circuits perform specific computations, such as extracting relevant sensory features of stimuli or how circuits alter themselves to store new information. To investigate how neural circuits function we employ a combination of multi-photon imaging, electrophysiology, optogenetics and computational modelling.


Exploring Neural Circuits

 Some examples of the methods we employ to interrogate neural circuits

Wide field of view 2-photon imaging of inhibitory neurons responding to sensory stimulation

Wide field of view 2-photon imaging of inhibitory neurons responding to sensory stimulation


OMMI

We have developed Optical MultiModal Imaging (OMMI) enabling simultaneous imaging of structural, intrinsic-optical, and fluorescent signals

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Electrophysiology: Paired recording of mitral-mitral cell synapses in the main olfactory bulb

 

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Optogenetics: An image stack through the glomerular layer of a mouse expressing YFP-tagged Channelrhodopsin-2

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Computational modeling: A realistic model of a retinal ganglion cell and the excitatory and inhibitory synapses of the inner plexiform layer of the retina